mir-26a-5p [Neurosurgery Wiki]

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**[[miR 26a]]-5p** is a [[microRNA]] (miRNA) involved in regulating various cellular processes, including [[cell proliferation]], apoptosis, differentiation, and metabolism. It has been identified as a key regulator in several diseases, such as cancer, neurological disorders, and cardiovascular diseases.

### **Key Features:**
- **Family:** Belongs to the miR-26 family (including miR-26a and miR-26b).
- **Biological Function:** Regulates gene expression post-transcriptionally by binding to the 3' untranslated region (3' UTR) of target mRNAs, leading to their degradation or translational repression.
- **Role in Cancer:** Functions as a tumor suppressor or oncogene, depending on the cancer type. It has been linked to various malignancies, including glioblastoma, hepatocellular carcinoma, breast cancer, and colorectal cancer.
- **Neurological Relevance:** Implicated in neurodegenerative diseases and neuronal development.
- **Cardiovascular Effects:** Plays a role in heart function, vascular remodeling, and myocardial diseases.

Would you like more specific details on its mechanisms or involvement in a particular disease?