Meningioma immune response [Neurosurgery Wiki]

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====== Meningioma immune response ======

Meningiomas are known to be infiltrated by [[immune cell]]s including [[microglia]], [[macrophage]]s, [[B-cell]]s, and [[T-cell]]s. Several mechanisms contribute to decreased anti-tumor [[immune response]], allowing tumor growth and evasion of the [[immune system]].
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The tumor microenvironment of meningiomas often includes post germinal center B cell populations. These tumors invariably include a selected, antigen-experienced, effector T cell population enriched by those that express markers of an exhausted phenotype.
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In a study, Wang et al. used single-cell [[RNA sequencing]] to perform the first characterization of both non-tumor-associated human [[dura]] and primary [[meningioma]] samples. First, they revealed a complex [[immune microenvironment]] in human dura that is transcriptionally distinct from that of [[meningioma]]. In addition, they characterized a functionally diverse and heterogeneous landscape of non-[[immune cell]]s including [[endothelial cell]]s and [[fibroblast]]s. Through imaging [[mass cytometry]], they highlighted the spatial relationship among [[immune cell]] types and [[vasculature]] in non-tumor-associated dura. Utilizing [[T cell receptor]] [[sequencing]], they showed significant TCR overlap between matched dura and meningioma samples. Finally, they reported copy number variant heterogeneity within the [[meningioma]] samples
((Wang AZ, Bowman-Kirigin JA, Desai R, Kang LI, Patel PR, Patel B, Khan SM, Bender D, Marlin MC, Liu J, Osbun JW, Leuthardt EC, Chicoine MR, Dacey RG Jr, Zipfel GJ, Kim AH, DeNardo DG, Petti AA, Dunn GP. Single-cell profiling of human [[dura]] and [[meningioma]] reveals cellular meningeal landscape and insights into meningioma [[immune response]]. Genome Med. 2022 May 10;14(1):49. doi: 10.1186/s13073-022-01051-9. PMID: 35534852.)).