Show pageBacklinksCite current pageExport to PDFBack to top This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong. ====== Medulloblastoma, SHH-activated, and TP53-mutant ====== Typical in childhood. Male:female = 1:1. Predominant histologic variant: large cell/anaplastic. The putative cell of origin: cerebellar granule neuron cell precursors of the external granule cell layer and cochlear nucleus; less likely neural stem cells of the subventricular zone. Frequent genetic mutations: [[TP53]]. ▶ Classic morphology. Prognosis: high-risk tumor. Uncommon. ▶ Large cell/anaplastic morphology. Prognosis: high-risk tumor. Prevalent in ages 7–17 years. ▶ Desmoplastic/nodular morphology. Very rare. Uncertain clinical significance. medulloblastoma_shh-activated_and_tp53-mutant.txt Last modified: 2024/06/07 02:53by 127.0.0.1