Meaningful (Scientific Definition) [Neurosurgery Wiki]

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===== Meaningful (Scientific Definition) =====

**Meaningful** refers to research results, innovations, or interventions that have clear biological, clinical, or translational significance beyond mere technical success.

==== Characteristics of Meaningful Outcomes ====
  * Demonstrates functional or therapeutic impact
  * Solves a defined clinical or scientific problem
  * Offers improvement over existing alternatives
  * Relevance is supported by context and application

==== Non-Examples ====
  * Delivery of fluorescent proteins without therapeutic intent
  * Engineering complexity without biological justification
  * In vivo "proofs" that lack disease relevance

==== Example ====
A gene therapy that restores motor function in a Parkinson’s model is meaningful. Delivering Cas9 to random brain cells without editing or phenotype data is not.