MAPK14 [Neurosurgery Wiki]

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====== MAPK14 ======

Contribution of [[MAPK]]14 in the pathogenesis of [[multiple sclerosis]] (MS) has been proposed by several studies. Long non-coding RNA (lncRNA) have been suggested to be functionally linked with Mitogen-activated protein kinase 14 (MAPK14).

Expression levels of MAPK14 and its associated [[lncRNA]]s were measured in the circulation of MS patients compared with control subjects.

Expression levels of [[NORAD]] and [[RAD51-AS1]] were higher in total patients compared with controls (Expression ratio (95% CI) = 1.4 (1.04-1.89), P value = 0.015 and Expression ratio (95% CI) = 1.91 (1.43-2.6), P value = 0.0001, respectively). Conversely, [[ZNRD1]]ASP was under-expressed in cases compared with controls (Expression ratio (95% CI) = 0.61 (0.41-0.8), P value = 0.0005). In spite of the observed abnormal expression levels of these lncRNAs in the circulation of MS patients, their expressions were not correlated with Expanded Disability Status Scale (EDSS) score, disease duration or age at disease onset.

To sum up, the current investigation shows dysregulation of MAPK14-related lncRNAs in MS patients
((Ghafouri-Fard S, Gholipour M, Eslami S, Hussen BM, Taheri M, Samadian M, Omrani MD. Abnormal expression of MAPK14-related lncRNAs in the peripheral blood of patients with multiple sclerosis. Noncoding RNA Res. 2023 Apr 6;8(3):335-339. doi: 10.1016/j.ncrna.2023.03.006. PMID: 37091283; PMCID: PMC10114144.)).