Lung cancer pituitary metastases [Neurosurgery Wiki]

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====== Lung cancer pituitary metastases ======

====== Case reports ======

A 62-year-old [[woman]] with [[multiple sclerosis]] and no history of [[malignancy]], [[incidental]]ly presented with a diffusely enlarged and homogeneously enhancing [[pituitary gland]] associated with [[stalk]] enlargement. The clinical and biochemical evaluation revealed anterior [[hypopituitarism]] and [[diabetes insipidus]]. [[Hypophysitis]] was considered the most likely diagnosis. However, rapid visual deterioration and pituitary growth raised the suspicion of metastatic involvement. A search for systemic malignancy was performed, and CT revealed a [[lung]] mass, which proved to be a [[lung adenocarcinoma]]. Accordingly, the patient was started on [[immunotherapy]]. Resection of the pituitary lesion was performed, and histopathology analysis revealed metastatic [[lung adenocarcinoma]]. Following surgery, the patient underwent [[radiotherapy]]. More than 2 years after PM detection, the patient shows a clinically relevant response to antineoplastic therapy and no evidence of PM recurrence
((Lopes AM, Pereira J, Ribeiro I, Martins da Silva A, Queiroga H, Amaral C. Pituitary metastases unveiling a lung adenocarcinoma. Endocrinol Diabetes Metab Case Rep. 2021 Feb 26;2021:EDM200211. doi: 10.1530/EDM-20-0211. Epub ahead of print. PMID: 33865234.)).