LITAF [Neurosurgery Wiki]

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====== LITAF ======


[[Lipopolysaccharide]]-induced [[tumor necrosis factor]]-alpha factor is a protein that in humans is encoded by the LITAF gene. It is associated with Charcot–Marie–Tooth disease 1C.
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Yu et al. found that [[LITAF]], is up-regulated both in [[mRNA]] and protein in GBM tumors. Meanwhile, theye observed that high LITAF expression contributes to [[glioblastoma radioresistance]] cell lines (including [[U87]], [[U251]], DK, and AM-38 [[cell line]]s), indicated by [[knockout]] or [[knockdown]] of LITAF in cells sensitizing them to radiation treatment both [[in vitro]] and [[in vivo]]. Furthermore, they demonstrated that kavain, an active constituent of Piper methysticum Forst., effectively ablates GSC-like cells' (such as CD133 + U87, U251, DK, and AM38 populations) radioresistance in a LITAF-dependent manner.

In mechanism, the results indicated that 1) the elevation of LITAF in GBM cells activates the NF-κB pathway to promote mesenchymal transition, and 2) kavain disturbs STAT6B/LITAF protein interaction and then expels LITAF from the nucleus. Therefore, they considered that kavain may be a potential candidate to develop an irradiation therapy adjuvant for GBM
((Yu J, Shi J, Yuan F, Yin W, Zeng H, Ge L, Li H, Wang X. Kavain ablates the radio-resistance of IDH-wildtype glioblastoma by targeting LITAF/NF-κB pathway. Cell Oncol (Dordr). 2022 Dec 5. doi: 10.1007/s13402-022-00743-z. Epub ahead of print. PMID: 36464713.))