Leukocyte function associated antigen 1 [Neurosurgery Wiki]

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=====Leukocyte function associated antigen 1=====
Leukocyte function-associated antigen-1 (LFA-1) is a heterodimeric protein consisting of two subunits. LFA-1 plays a most important role in the immune system including adhesion, extravasation, migration, apoptosis, cytotoxicity, cytokine production, and proliferation of lymphocytes. Therefore, T-cell activation can be suppressed by blocking ICAM-1/LFA-1 interaction in autoimmune diseases and organ transplantation. Many different inhibitors (i.e. antibodies, peptides, small molecules) have been demonstrated to block ICAM-1/LFA-1 interaction, and some of them are promising for medical treatment or have reached clinical trials
((Xingyuan M, Wenyun Z, Tianwen W. Leukocyte function-associated antigen-1:
structure, function and application prospects. Protein Pept Lett.
2006;13(4):397-400. Review. PubMed PMID: 16712517.
)).
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The results of a study suggest LFA-1 as a new target in brain metastasis therapy and highlight the potential synergy with current anti-[[COX 2]] and anti-NOS therapies
((Soto MS, O'Brien ER, Andreou K, Scrace SF, Zakaria R, Jenkinson MD, O'Neill E,
Sibson NR. Disruption of tumour-host communication by downregulation of LFA-1
reduces COX-2 and e-NOS expression and inhibits brain metastasis growth.
Oncotarget. 2016 Jul 20. doi: 10.18632/oncotarget.10737. [Epub ahead of print]
PubMed PMID: 27447568.
)).