lats1 [Neurosurgery Wiki]

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Results showed the [[overexpression]] of [[YAP1]] and [[Survivin]] as well as a decreased activity of large tumor suppressor 1 ([[LATS1]]) in high-grade glioblastoma versus [[anaplastic astrocytoma]] and low-grade glioma. Furthermore, Aguennouz et al. also demonstrated that miR-221 and miR-10b are specifically involved in [[Hippo signaling pathway]] via [[LATS1]] regulation and that their [[knockdown]] significantly decreased [[glioma cell]] proliferation. This preliminary data confirmed the crucial role of the [[Hippo signaling pathway]] in cancer and suggested that [[miR 221]] and [[miR]] 10b could be potential therapeutic targets for glioma treatment
((Aguennouz M, Polito F, Visalli M, et al. microRNA-10 and -221 modulate differential expression of Hippo signaling pathway in human astroglial tumors [published online ahead of print, 2020 Aug 5]. Cancer Treat Res Commun. 2020;24:100203. doi:10.1016/j.ctarc.2020.100203)).