LAMP2 [Neurosurgery Wiki]

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====== LAMP2 ======

[[Lysosome]]-associated [[membrane protein]] 2, also known as CD107b and Mac-3, is a human gene. Its protein, LAMP2, is one of the lysosome-associated membrane [[glycoprotein]]s. The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with [[carbohydrate]] ligands.
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In a study, Zhu et al. found that [[chaperone-mediated autophagy]] (CMA) directly degrades Kelch-like ECH-associated protein 1 ([[Keap1]]), an adaptor of the E3 ligase complex that promotes the degradation of nuclear factor erythroid 2-related factor 2 ([[Nrf2]]), which is a master transcriptional regulator in antioxidative response. Activated CMA induced by prolonged [[oxidative stress]] led to an increase in [[Nrf2]] level by effectively degrading [[Keap1]], contributing to Nrf2 nuclear [[translocation]] and the expression of multiple downstream antioxidative genes. Meanwhile, together with a previous study showing that Nrf2 can also transcriptionally regulate [[LAMP2]]A, the rate-limiting factor of the CMA process, we reveal a feed-forward loop between CMA and Nrf2. The study identifies CMA as a previously unrecognized regulator of the [[Keap1]]-[[Nrf2]] pathway and reinforces the antioxidative role of [[chaperone-mediated autophagy]] (CMA)
((Zhu L, He S, Huang L, Ren D, Nie T, Tao K, Xia L, Lu F, Mao Z, Yang Q. Chaperone-mediated autophagy degrades Keap1 and promotes [[Nrf2]]-mediated antioxidative response. Aging Cell. 2022 May 10:e13616. doi: 10.1111/acel.13616. Epub ahead of print. PMID: 35535673.)).