iomm-lee [Neurosurgery Wiki]

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Like most [[tumor]]s, [[meningioma]]s prefer anaerobic [[glycolysis]] for energy production ([[Warburg effect]]). This leads to an increased synthesis of the metabolite [[methylglyoxal]] (MGO). This [[metabolite]] is known to react with amino groups of [[protein]]s. This reaction is called [[glycation]], thereby building advanced glycation endproducts (AGEs). In a study, Selke et al investigated the influence of glycation on two [[meningioma cell line]]s, representing the WHO grade I ([[BEN-MEN-1]]) and the WHO grade III ([[IOMM-Lee]]). Increasing MGO concentrations led to the formation of AGEs and decreased growth in both cell lines. When analyzing the influence of [[glycation]] on [[adhesion]], [[chemotaxis]] and [[invasion]], they could show that the [[glycation]] of [[meningioma]] cells resulted in increased invasive potential of the benign meningioma [[cell line]], whereas the invasive potential of the malignant cell line was reduced. In addition, [[glycation]] increased the [[E-cadherin]]- and decreased the [[N-cadherin]]-expression in [[BEN-MEN-1]] cells, but did not affect the [[cadherin]]-expression in [[IOMM-Lee]] cells
((Selke P, Rosenstock P, Bork K, Strauss C, Horstkorte R, Scheer M. Glycation of benign meningioma cells leads to increased invasion. Biol Chem. 2021 Mar 17. doi: 10.1515/hsz-2020-0376. Epub ahead of print. PMID: 33725749.)).