intracranial_subarachnoid_aneurysm_trial [Neurosurgery Wiki]

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In the early 1990's, endovascular treatment using embolic coils for the treatment of [[intracranial aneurysm]]s was established. Since then, there has been a significant body of peer-reviewed literature written by medical experts regarding the use, safety, and efficacy of these detachable embolic coils. With the publishing of the [[ISAT]] ([[Intracranial Subarachnoid Aneurysm Trial]]) trial data in [[2005]], which compared clinical outcomes of neurosurgical clipping and endovascular coiling, embolic coiling became the preferred method for treatment of the majority of unruptured intracranial aneurysms 
((Molyneux AJ, Kerr RS, Yu LM, Clarke M, Sneade M, Yarnold JA, Sandercock P;
International Subarachnoid Aneurysm Trial (ISAT) Collaborative Group.
International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus
endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a
randomised comparison of effects on survival, dependency, seizures, rebleeding,
subgroups, and aneurysm occlusion. Lancet. 2005 Sep 3-9;366(9488):809-17. PubMed 
PMID: 16139655.
)).