Intracranial artery stenosis [Neurosurgery Wiki]

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====== Intracranial artery stenosis ======

Intracranial [[stenosis]] is the severe narrowing of an [[artery]] within the [[skull]]. A blood vessel narrows when fatty deposits (plaque) build up inside the vessel, a condition known as [[atherosclerosis]]. Stenosis can restrict [[blood flow]] to areas of the brain, increasing the risk of [[stroke]].
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Higher circulating [[PCSK9]] levels were independently associated with an [[intracranial artery stenosis]] ([[ICAS]]) prevalence but not with a [[cerebral small vessel disease]] (CSVD) prevalence. The quantification of circulating PCSK9 levels may help to identify individuals at high risk for cerebrovascular disease in the general population
((Kunimura A, Yano Y, Hisamatsu T, Torii S, Kondo K, Kadota A, Fujiyoshi A, Okamura T, Watanabe Y, Shiino A, Nozaki K, Ueshima H, Miura K; SESSA research group. Association between proprotein convertase subtilisin/kexin type 9 (PCSK9) and subclinical cerebrovascular disease in the community. Eur J Neurol. 2023 Feb 2. doi: 10.1111/ene.15723. Epub ahead of print. PMID: 36727585.)).