Intracerebral hemorrhage medical treatment [Neurosurgery Wiki]

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====== Intracerebral hemorrhage medical treatment ======

[[Blood pressure]] management [[drug]]s, [[Recombinant factor VIIa]], and [[tissue plasminogen activator]]
have been used for improving [[primary brain injury]] by reducing blood pressure and inhibiting hematoma expansion after ICH
(( Wilkinson DA, Pandey AS, Thompson BG, Keep RF, Hua Y, Xi
G. Injury mechanisms in acute intracerebral hemorrhage.
Neuropharmacology. 2018;134(Pt B):240–8.))
((Dornak, T., M. Kral, Z. Sedlackova, D. Sanak, E. Cechakova, P.
Divisova, et al., Predictors for intracranial hemorrhage following
intravenous thrombolysis in posterior circulation stroke. Transl
Stroke Res, 2018.))
((Bhatia PM, Chamberlain R, Luo X, Hartley EW, Divani AA.
Elevated blood pressure causes larger hematoma in a rat model of
intracerebral hemorrhage. Transl Stroke Res. 2012;3(4):428–34)).

Many compounds, [[recombinant protein]]s, [[drug]]s and other agents including [[glibenclamide]], [[suberoylanilide hydroxamic acid]], [[adropin]], [[C1qtnf9]], [[melatonin]] and so on, have been reported to exhibit neuroprotective effects during ICH via reducing neuronal cell apoptosis, inhibiting inflammation or protecting BBB
(( Wang Z, Zhou F, Dou Y, Tian X, Liu C, Li H, et al. Melatonin
alleviates intracerebral hemorrhage-induced secondary brain injury
in rats via suppressing apoptosis, inflammation, oxidative
stress, DNA damage, and mitochondria injury. Transl Stroke
Res. 2018;9(1):74–91.))
((Jiang B, Li L, Chen Q, Tao Y, Yang L, Zhang B, et al. Role of
glibenclamide in brain injury after intracerebral hemorrhage.
Transl Stroke Res. 2017;8(2):183–93.))
((Sukumari-Ramesh S, Alleyne CH Jr, Dhandapani KM. The histone
deacetylase inhibitor suberoylanilide hydroxamic acid
(SAHA) confers acute neuroprotection after intracerebral hemorrhage
in mice. Transl Stroke Res. 2016;7(2):141–8.))
((Yu L, Lu Z, Burchell S, Nowrangi D, Manaenko A, Li X, et al.
Adropin preserves the blood-brain barrier through a Notch1/Hes1
pathway after intracerebral hemorrhage in mice. J Neurochem.
2017;143(6):750–60.))
((Zhao L, Chen S, Sherchan P, Ding Y, Zhao W, Guo Z, et al.
Recombinant CTRP9 administration attenuates neuroinflammation
via activating adiponectin receptor 1 after intracerebral hemorrhage
in mice. J Neuroinflammation. 2018;15(1):215.)).

===== Antihypertensive Medication After Intracerebral Hemorrhage =====

[[Antihypertensive Medication After Intracerebral Hemorrhage]].