Insulin-like growth factor 1 receptor [Neurosurgery Wiki]

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====== Insulin-like growth factor 1 receptor ======

The [[insulin-like growth factor 1]] ([[IGF-1]]) receptor is a protein found on the surface of human cells. It is a [[transmembrane receptor]] that is activated by a hormone called insulin-like growth factor 1 (IGF-1) and by a related hormone called [[IGF-2.]] It belongs to the large class of [[tyrosine kinase receptor]]s. This receptor mediates the effects of IGF-1, which is a polypeptide protein hormone similar in molecular structure to insulin. IGF-1 plays an important role in growth and continues to have anabolic effects in adults – meaning that it can induce hypertrophy of skeletal muscle and other target tissues. Mice lacking the IGF-1 receptor die late in development, and show a dramatic reduction in body mass. This testifies to the strong growth-promoting effect of this receptor.