Infliximab [Neurosurgery Wiki]

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====== Infliximab ======

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**Infliximab** is a chimeric [[monoclonal antibody]] (human-murine) that inhibits **[[tumor necrosis factor]]-alpha ([[TNFα]])**. It is used to treat [[autoimmune disease]]s driven by this inflammatory [[cytokine]].

===== Indications =====

Infliximab is used to treat several chronic inflammatory diseases, including:

- **Rheumatologic diseases:**
  - [[Rheumatoid arthritis]] see [[Infliximab for rheumatoid arthritis]]
  - Ankylosing spondylitis
  - Psoriatic arthritis
- **Inflammatory bowel diseases:**
  - Crohn's disease
  - Ulcerative colitis
- **Dermatological conditions:**
  - Severe plaque psoriasis

===== Mechanism of Action =====

Infliximab specifically binds to **TNF-α**, blocking its activity and reducing inflammation. This helps alleviate symptoms and slow disease progression.


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Types of immunosuppressants include Biologics such as [[adalimumab]] (Humira®) and [[infliximab]] (Remicade®). Calcineurin inhibitors such as [[tacrolimus]] (Envarsus XR® or Protopic) and [[cyclosporine]] (Gengraf®, Neoral® or Sandimmune®). Corticosteroids ([[prednisone]])
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