IMAT1 [Neurosurgery Wiki]

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====== IMAT1 ======
[[Invasive meningioma]]-associated transcript 1 (IMAT1) is a [[long non-coding RNA]] located on Homo sapiens [[chromosome 17]] that were identified by Ding et al. based on absolute expression differences in invasive and non-invasive meningiomas. The studies indicated that IMAT1 was highly expressed in invasive [[meningioma]]s compared with non-invasive meningiomas. [[In vitro]] studies showed that IMAT1 promoted meningioma [[cell invasion]] through the inactivation of the Krüppel-like factor 4 ([[KLF4]])/hsa-miR22-3p/[[Snai1]] pathway by acting as a sponge for hsa-miR22-3p, and IMAT1 knockdown effectively restored the tumor-suppressive properties of KLF4 by preserving its [[tumor suppressor]] pathway. In vivo experiments confirmed that IMAT1 silencing could significantly inhibit the growth of subcutaneous tumors and prolong the survival period of tumor-bearing mice. The findings demonstrated that the high expression of IMAT1 is the inherent reason for the loss of the tumor-suppressive properties of [[KLF4]] during meningioma progression. Therefore, they believe that IMAT1 may be a potential biological [[marker]] and treatment target for meningiomas
((Ding Y, Ge Y, Wang D, Liu Q, Sun S, Hua L, Deng J, Luan S, Cheng H, Xie Q, Gong Y, Zhang T. LncRNA-IMAT1 Promotes Invasion of Meningiomas by Suppressing KLF4/hsa-miR22-3p/Snai1 Pathway. Mol Cells. 2022 Jun 30;45(6):388-402. doi: 10.14348/molcells.2022.2232. PMID: 35680373.))