HNF1A-AS1 [Neurosurgery Wiki]

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====== HNF1A-AS1 ======

[[Long non-coding RNA]]s (lncRNAs) have been proven to exert important functions in the various biological processes of human [[cancer]]s. It has been reported that lncRNA HNF1 homeobox A antisense RNA 1 (HNF1A-AS1) was abnormally expressed and played a role in the initiation and development of various human cancers. In a study, Bi et al. confirmed that the expression level of HNF1A-AS1 was increased in [[glioma]] [[tissue]]s and cells. [[Knockdown]] of HNF1A-AS1 inhibited [[cell proliferation]] and promoted cell [[apoptosis]] in [[glioma]]. Then, they disclosed the [[downregulation]] of [[miR]]-363-3p in glioma tissues and cell lines. The interaction between HNF1A-AS1 and miR-363-3p was identified in glioma cells. Furthermore, an inverse correlation between HNF1A-AS1 and miR-363-3p was observed in glioma tissues. Afterwards, they recognized that [[MAP2K4]] was a direct target of miR-363-3p. The expression of MAP2K4 was negatively correlated with miR-363-3p while positively related to HNF1A-AS1 in glioma tissues. They also found the regulatory effect of HNF1A-AS1 on the MAP2K4-dependent JNK signaling pathway. All findings indicated that HNF1A-AS1 induces the upregulation of MAP2K4 to activate the JNK signaling pathway to promote glioma cell growth by acting as a miR-363-3p sponge
((Bi Y, Mao Y, Su Z, Du J, Ye L, Xu F. Long non-coding RNA HNF1A-AS1 regulates proliferation and apoptosis of glioma through activation of the JNK signaling pathway via miR-363-3p/MAP2K4 [published online ahead of print, 2020 Aug 10]. J Cell Physiol. 2020;10.1002/jcp.29916. doi:10.1002/jcp.29916)).