Histone deacetylase (HDAC) [Neurosurgery Wiki]

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=====Histone deacetylase (HDAC)=====

see also [[Histone deacetylase inhibitor]].

Histone deacetylases (EC 3.5.1.98, HDAC) are a class of [[enzyme]]s that remove [[acetyl]] groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on a [[histone]], allowing the histones to wrap the DNA more tightly. This is important because DNA is wrapped around histones, and DNA expression is regulated by acetylation and de-acetylation. Its action is opposite to that of histone acetyltransferase. HDAC proteins are now also called lysine deacetylases (KDAC), to describe their function rather than their target, which also includes non-histone proteins
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[[Histone]] deacetylases (HDACs) play a role in the [[tumorigenesis]] of [[glioblastoma multiforme]] (GBM), whereas the underlying mechanism has not been elucidated. 

see [[Histone deacetylase 1]]

see [[Histone deacetylase 2]]

see [[Histone deacetylase 3]]

see [[Histone deacetylase 6]]
 
see [[Histone deacetylase 9]]

see [[Histone deacetylase 11]]