GPR101 [Neurosurgery Wiki]

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=====GPR101=====
Probable G-protein coupled receptor 101 is a [[protein]] that in humans is encoded by the GPR101 [[gene]].

G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.

A duplication event in GPR101 is implicated in cases of [[gigantism]] and [[acromegaly]].

Germline GPR101 mutations are very rare in patients with sporadic [[pituitary neuroendocrine tumor]]s of various histotypes. No digenism with AIP was identified. Further studies are required to establish whether and how genetic variation in GPR101 gene contributes to pituitary [[tumorigenesis]]
((Lecoq AL, Bouligand J, Hage M, Cazabat L, Salenave S, Linglart A, Young J,
Guiochon-Mantel A, Chanson P, Kamenicky P. Very low frequency of germline GPR101 
genetic variation and no biallelic defects with AIP in a large cohort of patients
with sporadic pituitary neuroendocrine tumors. Eur J Endocrinol. 2016 Jan 20. pii:
EJE-15-1044. [Epub ahead of print] PubMed PMID: 26792934.))