Glioma cell line [Neurosurgery Wiki]

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====== Glioma cell line ======

===== C6 =====
[[C6 cancer cell line]]  

===== GSC23 =====

[[GSC23]]

===== J3T =====
[[J3T]]

===== LN229 =====

[[LN229]]

===== SNB19 =====
[[SNB19]]

===== T98G =====
[[T98G]] 

===== U87 =====

[[U87]]MG

===== U105 =====
[[U105]]

===== U251 =====
[[U251]]

===== U373 MG =====
[[U373]] MG






mis-cultured [[glioma cell]]s can acquire unnatural drug sensitivity, which would have devastating effects for clinical translations
((Ledur PF, Onzi GR, Zong H, Lenz G. Culture conditions defining glioblastoma
cells behavior: what is the impact for novel discoveries? Oncotarget. 2017 Aug
11;8(40):69185-69197. doi: 10.18632/oncotarget.20193. eCollection 2017 Sep 15.
Review. PubMed PMID: 28978189; PubMed Central PMCID: PMC5620329.
)).

In 2006, inspired by [[neural stem cell]] (NSC) culture conditions, the Fine lab used serum-free, EGF/FGF-2-supplemented [[Neurobasal]] medium to cultivate primary glioma cells and found that these cells remained more similar to the parental tumors than those cultured in serum-containing DMEM medium 
((Lee J, Kotliarova S, Kotliarov Y, Li A, Su Q, Donin NM, Pastorino S, Purow BW,
Christopher N, Zhang W, Park JK, Fine HA. Tumor stem cells derived from
glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and
genotype of primary tumors than do serum-cultured cell lines. Cancer Cell. 2006
May;9(5):391-403. PubMed PMID: 16697959.
)).

[[Extracellular vesicle]]s secreted by human [[glioma cell]]s contain a wealth of [[tumor]]-specific [[protein]]s and [[nucleic acid]]s that can be isolated from [[patient]]s with these [[neoplasm]]s. Thus, EV contribute to the development of [[biomarker]]s, and additionally have certain therapeutic potential for possible use in [[neurooncology]] and [[neurosurgery]]
((Santiago-Dieppa DR, Gonda DD, Cheung VJ, Steinberg JA, Carter BS, Chen CC.
Extracellular Vesicles as a Platform for Glioma Therapeutic Development. Prog
Neurol Surg. 2018;32:172-179. doi: 10.1159/000469689. Epub 2018 Jul 10. PubMed
PMID: 29990983.
)).
----
Results suggest that [[glioma cell]]s themselves express [[Angiopoietin 2]] and that expression may be induced by hypoxic stimulation and may play a crucial role in the vessel maturation, [[angiogenesis]], and vessel regression in [[malignant glioma]]
((Koga K, Todaka T, Morioka M, Hamada J, Kai Y, Yano S, Okamura A, Takakura N,
Suda T, Ushio Y. Expression of angiopoietin-2 in human glioma cells and its role 
for angiogenesis. Cancer Res. 2001 Aug 15;61(16):6248-54. PubMed PMID: 11507079.
)).