Glioblastoma Radiotherapy [Neurosurgery Wiki]

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====== Glioblastoma Radiotherapy ======
Historically, the treatment for [[glioblastoma]] had consisted of [[maximal safe resection]] followed by an adjuvant [[nitrosourea]], with trials by the Brain Tumor Study Group demonstrating evidence for post-op [[Radiotherapy]] over best [[supportive care]]
((Walker MD, Green SB, Byar DP, Alexander E, Jr, Batzdorf U, Brooks WH, et al. Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery. N Engl J Med (1980) 303:1323–9.10.1056/NEJM198012043032303))
((Walker MD, Alexander E, Jr, Hunt WE, MacCarty CS, Mahaley MS, Jr, Mealey J, Jr, et al. Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas. A cooperative clinical trial. J Neurosurg (1978) 49:333–43.10.3171/jns.1978.49.3.0333)).

Further analysis of the relationship between survival and [[radiation]] dose revealed a dose–effect relationship, with doses of 60 Gy providing superior [[survival]] when compared to lower doses
((Walker MD, Strike TA, Sheline GE. An analysis of dose-effect relationship in the radiotherapy of malignant gliomas. Int J Radiat Oncol Biol Phys (1979) 5:1725–31.10.1016/0360-3016(79)90553-4 )).

===== Glioblastoma Stereotactic Radiosurgery =====
[[Glioblastoma Stereotactic Radiosurgery]]



===== Glioblastoma Radioresistance =====
[[Glioblastoma Radioresistance]]