gigantol [Neurosurgery Wiki]

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Greater [[matrix stiffness]] could obviously up-regulate the expression of [[BCL9L]], thereby promoting the activation of [[Wnt]]/[[beta-catenin]] [[signaling]] and ultimately increasing the stemness of [[glioma cell]]s. Inhibiting Wnt/beta-catenin signaling using [[gigantol]] consistently improved the anticancer effects of [[chemotherapy]] and [[radiotherapy]] in mice with subcutaneous glioma tumors. These findings demonstrate that a stiffer matrix increases the stemness of glioma cells by activating BCL9L/Wnt/beta-catenin signaling. Moreover, they provided a potential strategy for clinical glioma treatment by demonstrating that gigantol can improve the effectiveness of traditional chemotherapy/radiotherapy by suppressing Wnt/beta-catenin signaling
((Tao B, Song Y, Wu Y, Yang X, Peng T, Peng L, Xia K, Xia X, Chen L, Zhong C. Matrix stiffness promotes glioma cell stemness by activating BCL9L/Wnt/beta-catenin signaling. Aging (Albany NY). 2021 Feb 1;12. doi: 10.18632/aging.202449. Epub ahead of print. PMID: 33535177.)).