Gene expression analysis [Neurosurgery Wiki]

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====== Gene expression analysis ======
[[Gene expression]] [[analysis]] such as [[microarray]]s and [[RNA sequencing]] (RNA-Seq) are used to analyze [[gene expression]] patterns. They provide insights into which [[gene]]s are active in a particular cell or tissue under specific conditions.
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The study of the way genes are transcribed to synthesize functional gene products — functional RNA species or protein products. The study of gene regulation provides insights into normal cellular processes, such as differentiation, and abnormal or pathological processes.
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Many [[circular RNAs]] are expressed in a tissue- and developmental-stage-specific manner, reveal a striking regulation of circRNAs during neuronal development, and detect their presence at synaptic sites. The exact functions of circRNAs remain poorly understood, but evidence from analysis of some circRNA molecules suggests that they could substantially contribute to the regulation of [[gene expression]], particularly in architecturally complex and polarized cells such as neurons.