GBA1 [Neurosurgery Wiki]

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====== GBA1 ======
[[GBA1-associated parkinsonism]]

It is clear that the [[immune system]] and [[inflammation]] have a role in [[Parkinson's disease]] (PD), including sporadic Parkinson's disease and some genetic forms such as [[LRRK2]]-associated Parkinson's disease. One of the most important genes associated with PD is [[GBA1]], as mutations in this [[gene]] are found in 5-20% of PD patients in different populations worldwide. Biallelic mutations in GBA1 may cause [[Gaucher disease]], a lysosomal storage disorder with involvement of the immune system, and other lines of evidence link GBA1 to the immune system and inflammation
((Al-Azzawi ZAM, Arfaie S, Gan-Or Z. GBA1 and The Immune System: A Potential Role in Parkinson's Disease? J Parkinsons Dis. 2022 Aug 29. doi: 10.3233/JPD-223423. Epub ahead of print. PMID: 36057834.)).