G-banding [Neurosurgery Wiki]

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====== G-banding ======

G-banding, G banding or Giemsa banding is a technique used in cytogenetics to produce a visible karyotype by staining condensed chromosomes. It is useful for identifying genetic diseases through the photographic representation of the entire chromosome complement.
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Findings suggest that [[G-banding]] is not a suitable test for [[1p/19q co-deletion]] analysis. Within these limits considering cost per diagnosis, and using [[FISH]] as a reference, [[Multiplex ligation-dependent probe amplification]] (MLPA) was marginally more cost-effective than other tests, although these economic analyses were limited by the range of available parameters, time horizon, and data from multiple health care organizations
((Brandner S, McAleenan A, Jones HE, Kernohan A, Robinson T, Schmidt L, Dawson S, Kelly C, Leal ES, Faulkner CL, Palmer A, Wragg C, Jefferies S, Vale L, P T Higgins J, Kurian KM. Diagnostic accuracy of 1p/19q codeletion tests in oligodendroglioma: a comprehensive meta-analysis based on a Cochrane Systematic Review. Neuropathol Appl Neurobiol. 2021 Dec 26. doi: 10.1111/nan.12790. Epub ahead of print. PMID: 34958131.)).