Show pageBacklinksCite current pageExport to PDFBack to top This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong. Fibronectin is a high-molecular weight (~440kDa) [[glycoprotein]] of the [[extracellular matrix]] that binds to membrane-spanning receptor proteins called [[integrin]]s. Similar to integrins, fibronectin binds extracellular matrix components such as collagen, fibrin, and heparan sulfate proteoglycans (e.g. syndecans). ---- [[Alpha-5 beta-1]] (α5β1), also known as the [[fibronectin]] receptor, is an [[integrin]] that binds to matrix macromolecules and proteinases and thereby stimulates [[angiogenesis]]. It is composed of α5 (ITGA5/CD49e) and β1 (ITGB1/CD29) subunits. It is the primary receptor for fibronectin. The interaction of VLA-5 with fibronectin plays an important role in regulating inflammatory cytokine production by human articular chondrocytes (From the Cell Migration Gateway ITGA5 ITGB1). α5β1-integrin is transported inside the cell by the kinesin KIF1C, a kinesin-3 organelle transporter that walks along microtubules. fibronectin.txt Last modified: 2024/06/07 02:56by 127.0.0.1