Fibrin degradation product [Neurosurgery Wiki]

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====== Fibrin degradation product ======

[[D-dimer]] (a specific fibrin degradation product): high levels are associated with Deep-vein thrombosis and PE
((Ginsberg JS, Wells PS, Kearon C, et al. Sensitivity and Specificity of a Rapid Whole-Blood Assay for D- dimer in the Diagnosis of Pulmonary Embolism. Ann Intern Med. 1998; 129:1006–1011)).
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[[D-dimer]]: a [[fibrin degradation product]], showed a [[sensitivity]] of 97.1%, [[specificity]] of 91.2%, a [[negative predictive value]] of 99.6%, and a [[positive predictive value]] of 55.7% 
((Kosinski CM, Mull M, Schwarz M, et al. Do normal [[D-dimer]] levels reliably exclude [[cerebral]] [[sinus thrombosis]]? Stroke. 2004; 35:2820–2825))
for [[Cerebral venous sinus thrombosis diagnosis]]

A normal D-dimer level by a sensitive [[radioimmunoassay]] or [[ELISA]] may help identify patients with a low probability of [[cerebral venous thrombosis]] (Level II). However, if suspicion is high, further evaluation is indicated.