Show pageBacklinksCite current pageExport to PDFBack to top This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong. =====Fc endostatin===== Systemically or directly (local) delivered Fc [[endostatin]] (FcE) prolonged the survival of rats implanted with intracranial [[9L gliosarcoma]]. This benefit was further enhanced when mFc-endostatin was combined with the oral chemotherapeutic agent [[temozolomide]] (TMZ) ((Grossman R, Tyler B, Hwang L, Zadnik P, Lal B, Javaherian K, Brem H. Improvement in the standard treatment for experimental glioma by fusing antibody Fc domain to endostatin. J Neurosurg. 2011 Dec;115(6):1139-46. doi: 10.3171/2011.8.JNS11125. Epub 2011 Sep 16. PubMed PMID: 21923243. )). Fc endostatin (FcE) was safe and significantly inhibited new vessel growth in a rabbit corneal neovascularization model. Lower concentration FcE 2 exhibited better inhibition than FcE 20, consistent with previous FcE studies referencing a biphasic dose-response curve. Additional studies are necessary to further elucidate the efficacy and clinical potential of this novel [[angiogenesis inhibitor]] ((Yoshida J, Wicks RT, Zambrano AI, Tyler BM, Javaherian K, Grossman R, Daoud YJ, Gehlbach P, Brem H, Stark WJ. Inhibition of Corneal Neovascularization by Subconjunctival Injection of Fc-Endostatin, a Novel Inhibitor of Angiogenesis. J Ophthalmol. 2015;2015:137136. doi: 10.1155/2015/137136. Epub 2015 Sep 28. PubMed PMID: 26491546. )) fc_endostatin.txt Last modified: 2024/06/07 02:58by 127.0.0.1