Factor VII [Neurosurgery Wiki]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.

====== Factor VII ======
A decrease in FVII activity significantly contributes to the [[coagulopathy]] and progressive hemorrhagic injury (PHI) in patients with isolated [[traumatic brain injury]]
((Wu X, Du Z, Yu J, Sun Y, Pei B, Lu X, Tang Z, Yin M, Zhou L, Hu J. Activity of
factor VII in patients with isolated blunt traumatic brain injury: association
with coagulopathy and progressive hemorrhagic injury. J Trauma Acute Care Surg.
2014 Jan;76(1):114-20. doi: 10.1097/TA.0b013e3182a8fe48. PubMed PMID: 24368365.)).

FVIIa and prothrombin complex concentrate (PCC) appear more effective than fresh frozen plasma (FFP). 

Either FVIIa or PCC are reasonable options for reversal, but FVIIa is considerably more expensive and may have greater risk of [[INR]] rebound
((Woo CH, Patel N, Conell C, Rao VA, Faigeles BS, Patel MC, Pombra J, Akins PT, 
Axelrod YK, Ge IY, Sheridan WF, Flint AC. Rapid Warfarin Reversal in the Setting 
of Intracranial Hemorrhage: A Comparison of Plasma, Recombinant Activated Factor 
VII, and Prothrombin Complex Concentrate. World Neurosurg. 2014
Jan;81(1):110-115. doi: 10.1016/j.wneu.2012.12.002. Epub 2012 Dec 5. Review.
PubMed PMID: 23220122.
)).