Eslicarbazepine acetate [Neurosurgery Wiki]

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====== Eslicarbazepine acetate ======

Eslicarbazepine acetate (ESL) is a [[sodium channel blocker]] indicated for partial-onset seizures with or without secondary generalization, at a single daily dose. 
Results suggest that it is not necessary to routinely determine [[licarbazepine]] levels. In specific cases, licarbazepine levels can be useful to assess adherence to treatment and for personalized dose adjustment.
((de Toledo M, Valladares-Salado L, Cebrian-Escudero J, Diaz-Perez C, de la
Fuente E, Ferreiros R, Sanz-Sanz E, Vega-Piris L, Lagares A, Ovejero-Benito MC,
Sobrado M. Pharmacokinetic variability of [[eslicarbazepine]] in real clinical
practice. Epilepsy Behav. 2021 Sep 11;124:108284. doi:
10.1016/j.yebeh.2021.108284. Epub ahead of print. PMID: 34521058.)).
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2: Andermann E, Rosenfeld W, Penovich P, Rogin J, Cendes F, Carreño M, Ramsay
RE, Ben-Menachem E, Gama H, Rocha F, Soares-da-Silva P, Tosiello R, Blum D,
Grinnell T. Comparative analysis of the safety and tolerability of
eslicarbazepine acetate in older (≥60 years) and younger (18-59 years) adults.
Epilepsy Res. 2021 Jan;169:106478. doi: 10.1016/j.eplepsyres.2020.106478. Epub
2020 Oct 10. PMID: 33338829.

3: Allard J, Lawthom C, Henley W, Mclean B, Hudson S, Tittensor P, Rajakulendran
S, Ellawela S, Pace A, Shankar R. Eslicarbazepine acetate response in
intellectual disability population versus general population. Acta Neurol Scand.
2021 Mar;143(3):256-260. doi: 10.1111/ane.13368. Epub 2020 Nov 24. PMID:
33131083.

4: Andermann E, Biton V, Benbadis SR, Shneker B, Shah AK, Carreño M, Trinka E,
Ben-Menachem E, Biraben A, Rocha F, Gama H, Cheng H, Blum D; Study 301, 302 and
304 Investigators. Psychiatric and cognitive adverse events: A pooled analysis
of three phase III trials of adjunctive eslicarbazepine acetate for partial-
onset seizures. Epilepsy Behav. 2018 May;82:119-127. doi:
10.1016/j.yebeh.2017.12.017. Epub 2018 Mar 28. PMID: 29604484.

5: Palleria C, Cozza G, Khengar R, Libri V, De Sarro G. Safety Profile of the
Newest Antiepileptic Drugs: A Curated Literature Review. Curr Pharm Des.
2017;23(37):5606-5624. doi: 10.2174/1381612823666170809115429. PMID: 28799510.

6: Shorvon SD, Trinka E, Steinhoff BJ, Holtkamp M, Villanueva V, Peltola J, Ben-
Menachem E. Eslicarbazepine acetate: its effectiveness as adjunctive therapy in
clinical trials and open studies. J Neurol. 2017 Mar;264(3):421-431. doi:
10.1007/s00415-016-8338-2. Epub 2017 Jan 18. PMID: 28101651; PMCID: PMC5336540.