erythrolysis [Neurosurgery Wiki]

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The destruction or dissolution of red blood cells, with subsequent release of [[hemoglobin]].
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[[Erythrolysis]] after [[cerebral hemorrhage]] releases potential [[neurotoxin]]s, contributing to [[brain injury]] and [[edema]]. Alternatively, erythrocyte phagocytosis via [[microglia]] or [[macrophage]]s may limit the spill of [[neurotoxin]]s, therefore, limiting subsequent [[brain injury]]. The aim of a review was to discuss the process of [[phagocytosis]] of [[erythrocyte]]s by [[microglia]] or [[macrophage]]s after [[cerebral hemorrhage]], the effect of [[erythrolysis]] on [[brain injury]], novel mechanisms of erythrocyte and phagocyte [[egress]] from the brain, and exciting new targets in this pathway to attenuate brain injury. Understanding the fate of erythrocytes after cerebral hemorrhage may uncover additional potential interventions for clinical [[translational research]]
((Xia F, Keep RF, Ye F, Holste KG, Wan S, Xi G, Hua Y. The Fate of [[Erythrocyte]]s after Cerebral Hemorrhage. Transl Stroke Res. 2022 Jan 23. doi: 10.1007/s12975-021-00980-8. Epub ahead of print. PMID: 35066815.)).