Show pageBacklinksCite current pageExport to PDFBack to top This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong. =====Endothelin-1===== The vasoconstrictor endothelin-1 (ET-1) has been implicated in the pathogenesis of cerebral [[vasospasm]] and [[delayed cerebral ischemia]] following [[subarachnoid hemorrhage]]. Endothelin-1 (ET-1) seems to represent the contractile component in a network to modulate arterial tone, with NO representing the relaxant component. ET-1 is synthesized by vascular endothelial or smooth muscle cells. Endothelin Converting Enzyme-1 (ECE-1) is localized predominantly to endothelial cells, the apparent primary source of ET-1. The synthesis of ET-1 seems to be enhanced in the central nervous system in pathological conditions. Increased levels of ET-1 have been found in cerebrospinal fluid (CSF)and brain tissue after trauma, ischemia, and SAH. endothelin.txt Last modified: 2024/06/07 02:57by 127.0.0.1