Dysembryoplastic Neuroepithelial Tumor Pathology [Neurosurgery Wiki]

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====== Dysembryoplastic Neuroepithelial Tumor Pathology ======

Multinodularity at low-power is a key feature with [[neuroglia]]l columns comprised of bundles of [[axon]]s aligned perpendicular to the cortical surface. These columns are lined by [[oligodendroglia]]l like cells incorporated within a mucoid matrix with interspersed [[neuron]]s. Occasionally difficult to differentiate from [[oligodendroglioma]].

Two distinct forms
((Adada B, Sayed K. Dysembryoplastic neuroepithelial tumors. Contemp Neurosurg. 2004; 26:1–5))
(do not appear to have different prognoses):

Simple form: glioneural elements consisting of axon bundles perpendicular to the cortical sur- face, lined with oligodendroglial-like cells that are S-100 positive and GFAP negative. Normal appearing neurons floating in a pale eosinophilic matrix are scattered between these columns (no resemblance to ganglion cells, unlike gangliogliomas)

Complex form: glioneural elements as described above in the simple form, with glial nodules scattered throughout. The glial component may mimic a low-grade fibrillary astrocytoma. Foci of cortical dysplasia occur