Double-blinded randomized prospective controlled trial [Neurosurgery Wiki]

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====== Double-blinded randomized prospective controlled trial ======

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A double-[[blinded]], randomized, [[prospective]] [[controlled trial]] is a robust scientific [[study]] design used to evaluate the [[effective]]ness of [[intervention]]s. 
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[[Double-blinded]]

[[Randomized]]: Participants are assigned randomly to different intervention groups (such as different drugs or treatments) to ensure that the groups are as similar as possible at the start of the trial. Randomization minimizes selection bias.

[[Prospective]]: The trial is forward-looking, meaning the researchers begin with a hypothesis and collect data going forward in time, measuring the outcomes after interventions are administered.

[[Controlled]]: The trial includes at least one comparison group, often called the control group. In this case, it could involve comparing two treatments (e.g., lidocaine vs. papaverine) to determine which is more effective, or it might involve comparing an active treatment to a placebo.

This design is considered one of the gold standards for clinical trials because it minimizes biases and provides strong evidence about the efficacy of the interventions being tested.