Dopamine transporter [Neurosurgery Wiki]

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====== Dopamine transporter ======

The [[dopamine]] [[transporter]] is a [[protein]] that is responsible for regulating the concentration of the neurotransmitter dopamine in the brain by reuptaking it into [[presynaptic neuron]]s. It is a [[transmembrane protein]] that spans the [[cell membrane]] of dopamine-producing neurons and functions by removing dopamine from the synaptic cleft after it has been released from the presynaptic terminal.

The dopamine transporter plays a crucial role in the regulation of dopamine [[signaling]] in the brain and is a target for drugs used in the treatment of neurological and psychiatric disorders such as [[attention deficit hyperactivity disorder]] (ADHD) and [[Parkinson's disease]]. Drugs such as [[amphetamine]]s and [[cocaine]] also act on the dopamine transporter, leading to an increase in dopamine levels in the synaptic cleft and producing their characteristic psychoactive effects.
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[[Striatal dopamine transporter]]