Cytoskeletal remodeling [Neurosurgery Wiki]

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====== Cytoskeletal remodeling ======

[[Cell migration]] is an essential process from [[embryogenesis]] to [[cell death]]. This is tightly regulated by numerous [[protein]]s that help in the proper functioning of the cell. In diseases like [[cancer]], this process is deregulated and helps in the [[dissemination]] of tumor cells from the primary site to secondary sites initiating the process of [[metastasis]]. For metastasis to be efficient, cytoskeletal components like [[actin]], [[myosin]], and [[intermediate filament]]s and their associated proteins should co-ordinate in an orderly fashion leading to the formation of many cellular protrusions-like lamellipodia and filopodia and [[invadopodia]]. Knowledge of this process is the key to controlling the metastasis of [[cancer cell]]s that leads to death in 90% of patients
((Aseervatham, J. (2020). Cytoskeletal Remodeling in Cancer. Biology, 9(11). https://doi.org/10.3390/biology9110385)).
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Zhang et al crucially identified that [[KIF4A]] drives [[glioma]] [[growth]] by [[Rac1]]/[[Cdc42]] [[transcriptional repressor]]s to induce [[cytoskeletal remodeling]] in [[glioma cell]]s. [[Knockdown]] of KIF4A decreased [[RohA]], [[Rac1]], [[Cdc42]], [[Pak1]] and [[Pak2]] expression level. The study provided a prospect that KIF4A functions as an [[oncogene]] in glioma
((Zhang H, Meng S, Chu K, Chu S, Fan YC, Bai J, Yu ZQ. KIF4A drives glioma growth by transcriptional repression of Rac1/Cdc42 to induce cytoskeletal remodeling in glioma cells. J Cancer. 2022 Nov 21;13(15):3640-3651. doi: 10.7150/jca.77238. PMID: 36606197; PMCID: PMC9809311.)).