CXCL10 [Neurosurgery Wiki]

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====== CXCL10 ======
C-X-C motif chemokine ligand 10 (CXCL10) also known as Interferon gamma-induced protein 10 (IP-10) or small-inducible cytokine B10 is an 8.7 kDa protein that in humans is encoded by the CXCL10 gene.
C-X-C motif chemokine 10 is a small cytokine belonging to the CXC chemokine family.

===== Gene =====

The gene for CXCL10 is located on human chromosome 4 in a cluster among several other CXC [[chemokine]]s.

===== Function =====

CXCL10 is secreted by several cell types in response to IFN-γ. These cell types include monocytes, endothelial cells and fibroblasts.
CXCL10 has been attributed to several roles, such as chemoattraction for monocytes/macrophages, T cells, NK cells, and dendritic cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis.

This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3.

===== Clinical significance =====

[[CXCL10 clinical significance]].