Show pageBacklinksCite current pageExport to PDFBack to top This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong. Sampling of cerebrospinal fluid (CSF) is an essential step for early-phase drug development studies, and particularly for studies in neurology. As CSF drug concentrations reflect unbound drug concentrations in the brain, this procedure is of critical importance for gaining insight into the delivery of drugs that act on targets in the central nervous system (CNS). In addition, CSF biomarkers are vital for indicating pharmacodynamic action of CNS drugs in clinical trials, as well as providing an excellent basis for go/no go decisions in the drug development process. csf_sampling.txt Last modified: 2024/06/07 02:55by 127.0.0.1