Colorectal cancer intracranial metastases epidemiology [Neurosurgery Wiki]

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====== Colorectal cancer intracranial metastases epidemiology ======

{{rss>https://pubmed.ncbi.nlm.nih.gov/rss/search/1rCy-EQvCZSyxIycMq2ww2uEwBxZGJVchIx5LOnIzBPPpb0IOm/?limit=15&utm_campaign=pubmed-2&fc=20230103111453}}
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The incidence of [[brain metastases]] from [[Colorectal cancer]] is 0.6 to 3.2% and did not seem to increase over time. Development of BM is associated with young age, lung metastases, rectal primary and KRAS mutation. Increased awareness of brain involvement in patients with these characteristics is necessary
((Christensen TD, Spindler KL, Palshof JA, Nielsen DL. Systematic review: brain 
metastases from colorectal cancer--Incidence and patient characteristics. BMC
Cancer. 2016 Apr 1;16:260. doi: 10.1186/s12885-016-2290-5. Review. PubMed PMID:
27037031; PubMed Central PMCID: PMC4818396.
)).

Patients within a registry tended to be female, young in age, and harbored with higher rates of KRAS mutations. Whether routine surveillance brain scanning should be considered remains controversial given the relative rarity of developing brain metastases in mCRC and ultimately, most patients with central nervous system involvement die from their extracranial disease
((Tapia Rico G, Price TJ, Karapetis C, Piantadosi C, Padbury R, Roy A, Maddern
G, Moore J, Carruthers S, Roder D, Townsend AR. Brain metastasis in advanced
colorectal cancer: results from the South Australian metastatic colorectal cancer
(SAmCRC) registry. Cancer Biol Med. 2017 Nov;14(4):371-376. doi:
10.20892/j.issn.2095-3941.2017.0068. PubMed PMID: 29372103; PubMed Central PMCID:
PMC5785167.
)).