cimpact-4 [Neurosurgery Wiki]

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[[Pediatric low-grade glioma]]s were shown to be characterized by an [[array]] of distinct molecular aberrations. The [[cIMPACT-4]] consensus proposed pediatric [[low-grade glioma]]s of the diffuse type to be characterized by distinct molecular changes rather than distinct histological features.

Fukuoka et al. described a small series of pediatric [[oligodendroglioma]]-like tumors with [[BRAF V600E]] mutations. Interestingly, they exhibited molecular changes usually associated with adult [[high-grade glioma]]s: chromosome instability, [[chromosome 7]] gains, and [[chromosome 10]] loss, but had an indolent [[natural history]]
((Yang RR, Li KK, Liu APY, Chen H, Chung NY, Chan AKY, Li F, Tat-Ming Chan D, Mao Y, Shi ZF, Ng HK. Low-grade BRAF V600E mutant oligodendroglioma-like tumors of children may show EGFR and MET amplification. Brain Pathol. 2020 Oct 8. doi: 10.1111/bpa.12904. Epub ahead of print. PMID: 33032379.)).