Show pageBacklinksCite current pageExport to PDFBack to top This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong. ====== Chromosome 19 ====== The molecular hallmark feature of [[oligodendroglioma]] is [[codeletion]] of the short arm of [[chromosome 1]] (1p) and the long arm of [[chromosome 19]] (19q) ((Jenkins RB, Blair H, Ballman KV, Giannini C, Arusell RM, Law M, Flynn H, Passe S, Felten S, Brown PD, Shaw EG, Buckner JC. A t(1;19)(q10;p10) mediates the combined deletions of 1p and 19q and predicts a better prognosis of patients with oligodendroglioma. Cancer Res. 2006 Oct 15;66(20):9852-61. PubMed PMID: 17047046. )). Complete [[deletion]] of both the short arm of [[chromosome 1]] ([[1p]]) and the long arm of [[chromosome 19]] ([[19q]]) is pathognomonic for [[oligodendroglioma]] ((Louis DN, Perry A, Reifenberger G, et al. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a sum- mary. Acta Neuropathol. 2016; 131:803–820)) ((Stupp R, Brada M, van den Bent MJ, et al. High- grade glioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2014; 25 Suppl 3:iii93–ii101)) It is strongly associated with [[IDH mutation]] and is mutually exclusive of [[ATRX]] & [[TP53]] [[mutation]]s. ---- The following are some of the genes located on chromosome 19: A1BG: encoding protein Alpha-1-B glycoprotein ACSBG2: encoding enzyme Long-chain-fatty-acid—CoA ligase ANKRD24: encoding protein Ankyrin repeat domain-containing protein 24 ARMC6: encoding protein Armadillo repeat-containing protein 6 ATG4D: encoding protein Autophagy related 4D, cysteine peptidase ATP5SL: encoding protein ATP synthase subunit s-like protein ATPase ASNA1: encoding enzyme ATPase ASNA1 also known as arsenical pump-driving ATPase and arsenite-stimulated ATPase BTBD14B: encoding protein Nucleus accumbens-associated protein 1 CACTIN: encoding protein Cactin CCDC130: encoding protein Coiled-coil domain containing 130 CCDC151: encoding protein Coiled-coil domain containing 151 CCDC8: encoding protein Coiled-coil domain containing 8 CCDC94: encoding protein Coiled-coil domain containing 94 (CCDC94), DNASE2: encoding protein Deoxyribonuclease II, lysosomal EID2: ETV2: encoding protein Ets variant 2 HCST: encoding protein Hematopoietic cell signal transducer HRC: encoding protein Sarcoplasmic reticulum histidine-rich calcium-binding protein IFI30: encoding enzyme Gamma-interferon-inducible lysosomal thiol reductase IGFL3: encoding protein IGF like family member 3 KRTDAP: encoding protein Keratinocyte differentiation-associated protein LIM2: encoding protein Lens fiber membrane intrinsic protein LRG1: encoding protein Leucine-rich alpha-2-glycoprotein 1 LSM4: encoding protein U6 snRNA-associated Sm-like protein LSm4 LSR: encoding protein Lipolysis-stimulated lipoprotein receptor LYPD5: encoding protein LY6/PLAUR domain containing 5 MBOAT7: encoding enzyme Lysophospholipid acyltransferase 7 MOBKL2A: encoding enzyme Mps one binder kinase activator-like 2A MZF1-AS1: encoding protein MZF1 antisense RNA 1 NCLN: encoding protein Nicalin NFKBID: encoding protein Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor NOSIP: encoding enzyme Nitric oxide synthase-interacting protein NWD1: NACHT and WD repeat domain containing 1. OLFM2: encoding protein Olfactomedin 2 OSCAR: encoding protein Osteoclast-associated immunoglobulin-like receptor PALM: encoding protein Paralemmin PDCD5: encoding protein Programmed cell death protein 5 PLIN4: encoding protein Perilipin 4 PEX11G: peroxisomal biogenesis factor 11 gamma PLVAP: encoding protein Plasmalemma vesicle-associated protein PRR12: encoding protein Proline-rich 12 KLK3: The Prostate-specific antigen (PSA) PRX: Periaxin PTOV1: encoding protein Prostate tumor overexpressed gene 1 protein SBNO2: encoding protein Strawberry notch homolog 2 (Drosophila) SEPW1: encoding protein Selenoprotein W SFRS14: encoding protein Putative splicing factor, arginine/serine-rich 14 SFRS16: encoding protein Splicing factor, arginine/serine-rich 16 SLC5A5: Solute carrier family 5 (sodium iodide symporter), member 5 STK11: Serine/threonine kinase 11 (Peutz-Jeghers syndrome) TBCB: encoding protein Tubulin-folding cofactor B TECR: encoding enzyme Trans-2,3-enoyl-CoA reductase THOP1: encoding enzyme Thimet oligopeptidase TIMM50: encoding enzyme Mitochondrial import inner membrane translocase subunit TIM50 TIP39: encoding protein Tuberoinfundibular peptide of 39 residues TMED1: encoding protein Transmembrane emp24 domain-containing protein 1 TMEM160: encoding protein Transmembrane protein 160 TMEM205: encoding protein Transmembrane Protein 205 UBXN6: encoding protein UBX domain protein 6 UCA1: a long non-coding RNA Urothelial cancer associated 1 UPK1A: encoding protein Uroplakin-1a USE1: encoding protein Uncharacterized hematopoietic stem/progenitor cells protein MDS032 Zfp82 zinc finger protein: encoding protein ZFP82 zinc finger protein ZSCAN18: encoding protein Zinc finger and SCAN domain containing 18 ZNF112: encoding protein Zinc finger protein 112 ZNF134: encoding protein Zinc finger protein 134 ZNF160: encoding protein Zinc finger protein 160 ZNF180: encoding protein Zinc finger protein 180 ZNF208: encoding protein Zinc finger protein 208 ZNF224: encoding protein Zinc finger protein 224 ZNF225: encoding protein Zinc finger protein 225 ZNF226: encoding protein Zinc finger protein 226 ZNF229: encoding protein Zinc finger protein 229 ZNF257: encoding protein Zinc finger protein 257 ZNF264: encoding protein Zinc finger protein 264 ZNF266: encoding protein Zinc finger protein 266 ZNF274: encoding protein Zinc finger protein 274 ZNF331: encoding protein Zinc finger protein 331 ZNF347: encoding protein Zinc finger protein 347 ZNF426: encoding protein Zinc finger protein 426 ZNF473: encoding protein Zinc finger protein 473 ZNF506: encoding protein Zinc finger protein 506 ZNF507: encoding protein Zinc finger protein 507 ZNF536: encoding protein Zinc finger protein 536 ZNF541: encoding protein Zinc finger protein 541 ZNF557: encoding protein Zinc finger protein 557 ZNF571: encoding protein Zinc finger protein 571 ZNF576: encoding protein Zinc finger protein 576 Zinc finger protein 613: encoding protein Zinc finger protein 613 ZNF649: Transcriptional suppressor ZNF71: encoding protein Endothelial zinc finger protein induced by tumor necrosis factor alpha ZNF737: encoding protein Zinc finger protein 737 ZNF749: encoding protein Zinc finger protein 749 ZNF676: encoding protein Zinc finger protein 676 ZNF772: encoding protein Zinc finger protein 772 ZNF784: encoding protein Zinc finger protein 784 ZNF8: encoding protein Zinc finger protein 8 ZNF83: encoding protein Zinc finger protein 83 ZNF878: encoding protein Zinc finger protein 878 ZNF880: encoding protein Zinc finger protein 880 Short arm CACNA1A: Calcium channel, voltage-dependent, P/Q type, alpha 1A subunit (Familial hemiplegic migraine Type I). Gene map locus 19p13 COMP: Cartilage oligomeric matrix protein. Gene map locus 19p13.1 NOTCH3: Notch homolog 3 (Drosophila): Gene map locus 19p13.1-p13.2 GCDH: Glutaryl-Coenzyme A dehydrogenase. Gene map locus 19p13.2 BSG: Basigin (Ok blood group)/Extracellular matrix metalloproteinase inducer/CD147. Gene map locus 19p13.3 ICAM4: Landsteiner and Weiner glycoprotein. Gene map locus 19p13.3 NRTN: Neurturin, associated with Hirschsprung's disease: Gene locus map 19p13.3 HCL1: Hair Colour 1; Brown hair colour; BRHC. Gene map locus 19p13.1-q13.11 OMIM: 113750 EYCL1: Eye Colour 1; Eye colour, green/blue; GEY. Gene map locus 19p13.1-q13.11 OMIM: 227240 GTPBP3: GTP binding protein 3 19p13.11 KLF2: Krüppel-like factor 2, also known as Lung Krüppel-like factor. Gene map locus 19p13.11 OMIM: 602016 FAM32A: family with sequence similarity 32 member A 19q13.11 DDX39: DExD-box helicase 39. Gene map locus 19p13.12 Long arm GAPDHS: glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 19q13.12 HAMP: Hepcidin antimicrobial peptide. Gene map locus 19q13.12 BCKDHA: Branched chain keto acid dehydrogenase E1, alpha polypeptide (maple syrup urine disease). Gene map location 19q13.1-q13.2 APOE: Apolipoprotein E, gene associated with Alzheimer's disease. Gene map locus 19q13.2 CIC: Capicua transcriptional repressor. Gene map locus 19q13.2 FCGBP: Fc fragment of IgG binding protein SARS2: seryl-tRNA synthetase 2, mitochondrial. Gene map locus 19q13.2 [[ATP1A3]]: ATPase. Gene map locus 19q13.31 DMWD: DM1 locus, WD repeat containing. Gene map locus 19q13.32 PNMA8A: paraneoplastic Ma antigen family member 8A 19q13.32 DMPK: Dystrophia myotonica-protein kinase. Gene map locus 19q13.32 GLTSCR2: Glioma tumor suppressor candidate region gene 2 protein 19q13.33 A1BG: Plasma glycoprotein, unknown function. Gene map locus 19q13.43 LRC: The Leukocyte Receptor Complex is a family of immunoreceptors expressed predominantly on monocytes and B cells and at lower levels on dendritic cells and natural killer (NK) cells. The LRC also includes the KIR locus. Gene map locus 19q13.4 OMIM: 604812 KPTN: Kaptin (actin binding protein) at the tips of stereocilia. Gene map locus 19q13.4[11] FUT1: The H locus is located on chromosome 19 at 19q13.3. It contains three exons that span more than 5 kb of genomic DNA, and it encodes a fucosyltransferase that produces the H antigen on RBCs.[12] FUT2: The Se locus is located on chromosome 19 at 19q13.3. It contains two exons that span about 25 kb of genomic DNA. The Se locus encodes a specific fucosyltransferase that is expressed in the epithelia of secretory tissues, such as salivary glands, the gastrointestinal tract, and the respiratory tract. The enzyme it encodes catalyzes the production of H antigen.[12] MORT (Mortal Obligate RNA Transcript, lincRNA): Gene map locus 19q13.43 chromosome_19.txt Last modified: 2024/06/07 02:58by 127.0.0.1