Ceftaroline [Neurosurgery Wiki]

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====== Ceftaroline ======

Results suggest that the antibacterial activity of both ceftaroline and vancomycin are similar in the treatment of MRSA meningitis in an experimental rabbit meningitis model.
((Mermer S, Turhan T, Bolat E, Aydemir S, Yamazhan T, Pullukcu H, Arda B,
Sipahi H, Ulusoy S, Sipahi OR. Ceftaroline versus vancomycin in the treatment of
methicillin-resistant Staphylococcus aureus (MRSA) in an experimental MRSA
meningitis model. J Glob Antimicrob Resist. 2020 Sep;22:147-151. doi:
10.1016/j.jgar.2020.02.001. Epub 2020 Feb 14. PMID: 32068093.)).
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Roujansky et al. observed than even in the case of mild meningeal inflammation, ceftaroline penetration in CSF, although moderate, enabled efficient bacterial clearance and clinical efficacy, in adjunction to correct ventriculoperitoneal shunt management.
((Roujansky A, Martin M, Gomart C, Hulin A, Mounier R. Multidrug-Resistant
Staphylococcus epidermidis Ventriculostomy-Related Infection Successfully
Treated by Intravenous Ceftaroline after Failure of Daptomycin Treatment. World
Neurosurg. 2020 Apr;136:221-225. doi: 10.1016/j.wneu.2020.01.013. Epub 2020 Jan
10. PMID: 31931253.)).
----


3: Chen CW, Chang SP, Huang HT, Tang HJ, Lai CC. The efficacy and safety of
ceftaroline in the treatment of acute bacterial infection in pediatric patients
- a systemic review and meta-analysis of randomized controlled trials. Infect
Drug Resist. 2019 May 15;12:1303-1310. doi: 10.2147/IDR.S199978. PMID: 31190919;
PMCID: PMC6526920.

4: Ebot J, Freeman WD, Wharen R, Diaz MA, Libertin C. MRSA Spinal Epidural
Abscess as a Neurosurgical and Infectious Disease Emergency with Unresolved
Antimicrobial Solution. Case Rep Infect Dis. 2019 Jan 30;2019:7413089. doi:
10.1155/2019/7413089. PMID: 30838147; PMCID: PMC6374787.

5: Chauzy A, Nadji A, Combes JC, Defrance N, Bouhemad B, Couet W, Chavanet P.
Cerebrospinal fluid pharmacokinetics of ceftaroline in neurosurgical patients
with an external ventricular drain. J Antimicrob Chemother. 2019 Mar
1;74(3):675-681. doi: 10.1093/jac/dky489. PMID: 30535190.

6: Stein GE, Yasin F, Smith C, Scharmen A, Havlichek D, Bill C. A
pharmacokinetic/pharmacodynamic analysis of ceftaroline prophylaxis in patients
with external ventricular drains. Surg Infect (Larchmt). 2015 Apr;16(2):169-73.
doi: 10.1089/sur.2014.098. Epub 2015 Mar 31. PMID: 25826463.

7: Kuriakose SS, Rabbat M, Gallagher JC. Ceftaroline CSF concentrations in a
patient with ventriculoperitoneal shunt-related meningitis. J Antimicrob
Chemother. 2015 Mar;70(3):953-4. doi: 10.1093/jac/dku464. Epub 2014 Nov 23.
PMID: 25422288.

8: Bucheit J, Collins R, Joshi P. Methicillin-resistant Staphylococcus aureus
epidural abscess treated with ceftaroline fosamil salvage therapy. Am J Health
Syst Pharm. 2014 Jan 15;71(2):110-3. doi: 10.2146/ajhp130246. PMID: 24375602.