Cefepime [Neurosurgery Wiki]

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====== Cefepime ======

Cefepime is a fourth-generation [[cephalosporin]] [[antibiotic]]. Cefepime has an extended spectrum of activity against Gram-positive and Gram-negative bacteria, with greater activity against both types of organisms than third-generation agents.

A 2007 meta-analysis suggested when data of trials were combined, mortality was increased in people treated with cefepime compared with other β-lactam antibiotics.

In response, the U.S. Food and Drug Administration performed its own meta-analysis which found no mortality difference.

Cefepime was developed by Bristol-Myers Squibb and marketed beginning in 1994. It is now available as a generic drug and sold under a variety of trade names worldwide.
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For a [[superficial wound infection]] start the patient empirically on [[vancomycin]] plus [[cefepime]] or [[meropenem]]