CBX7 [Neurosurgery Wiki]

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====== CBX7 ======

Polycomb repressor complex 1-chromobox7 ([[CBX7]]) has emerged as a key regulator in several cellular processes including stem cell self-renewal and cancer cell proliferation. The hypoxic environment triggering NPC self-renewal after CBX7 activation remains unknown. 

In a study, Chiu et al. found that the upregulation of CBX7 during [[hypoxia]] and [[ischaemia]] appeared to be from hypoxia-inducible factor-1α (HIF-1α) activation. During hypoxia, the HIF-1α-CBX7 cascade modulated NPC proliferation in vitro. NPC numbers significantly decreased in CBX7 knockout mice generated using CRISPR/Cas9 genome editing.

Chiu et al. provided the novel insight that CBX7 expression is regulated through HIF-1α activation, which plays an intrinsically modulating role in NPC proliferation
((Chiu HY, Lee HT, Lee KH, Zhao Y, Hsu CY, Shyu WC. Mechanisms of ischaemic
neural progenitor proliferation: a regulatory role of the HIF-1α-CBX7 pathway.
Neuropathol Appl Neurobiol. 2019 Oct 19. doi: 10.1111/nan.12585. [Epub ahead of
print] PubMed PMID: 31630421.
)).