Calcium channel [Neurosurgery Wiki]

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====== Calcium channel ======

A [[calcium]] channel is an [[ion channel]] which shows selective permeability to [[calcium]] ions. It is sometimes synonymous as voltage-gated calcium channel, although there are also ligand-gated calcium channels.

Sun et al., show that [[oligodendrocyte progenitor cell]]s perform linear integration of [[glutamate]]rgic synaptic inputs and respond with increasing dendritic [[calcium]] elevations. Synaptic activity induces rapid Ca2+ signals mediated by low-voltage activated [[Calcium channel]]s under strict inhibitory control of voltage-gated A-type K+ channels. Ca2+ signals can be global and originate throughout the cell. However, voltage-gated channels are also found in thin [[dendrite]]s which act as compartmentalized processing units and generate local calcium transients. Taken together, the activity-dependent control of Ca2+ signals by A-type channels and the global versus local signaling domains make intracellular Ca2+ in NG2 cells a prime signaling molecule to transform [[neurotransmitter]] release into activity-dependent myelination
((Sun W, Matthews EA, Nicolas V, Schoch S, Dietrich D. NG2 glial cells integrate
synaptic input in global and dendritic calcium signals. Elife. 2016 Sep 19;5.
pii: e16262. doi: 10.7554/eLife.16262. [Epub ahead of print] PubMed PMID:
27644104.
)).