c-MET [Neurosurgery Wiki]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
====== c-MET ======


[[c-Met]], also called [[tyrosine-protein kinase]] Met or [[hepatocyte growth factor receptor]] (HGFR), is a protein that in humans is encoded by the MET gene.

[[C-MET inhibitor]].
----
Dismal [[glioblastoma outcome]] ([[Glioblastoma]]) prompts for the identification of response predictors and therapeutic resistance mechanisms of current therapies. 
Carvalho et al. investigated the impact of [[c-Met]], [[HGF]], [[VEGFR2]] expression and [[microvessel density]] (MVD) in Glioblastoma patients submitted to second-line chemotherapy with [[bevacizumab]]. Immunohistochemical expression of c-Met, HGF, VEGFR2, and MVD was assessed in tumor specimens of Glioblastoma patients treated with bevacizumab, after progression under [[temozolomide]]. Survival analysis was evaluated according to the expression of the aforementioned biomarkers. c-Met overexpression was associated with a time-to-progression (TTP) after bevacizumab of 3 months (95% CI, 1.5-4.5) compared with a TTP of 7 months (95% CI, 4.6-9.4) in patients with low or no expression of c-Met (p = 0.05). VEGFR2 expression was associated with a TTP after bevacizumab of 3 months (95% CI, 1.8-4.2) compared with a TTP of 7 months (95% CI, 5.7-8.3) in patients with no tumoral expression of VEGFR2 (p = 0.009). Concomitant c-Met/VEGFR2 overexpression was associated with worse overall survival (13 months) compared with concomitant c-Met/VEGFR2 negative expression (19 months; p = 0.025). This data support the hypothesis that c-Met and VEGFR2 overexpression have a role in the development of glioblastoma early resistance and might predict poorer responses to anti-angiogenic therapies.
((Carvalho B, Lopes JM, Silva R, Peixoto J, Leitão D, Soares P, Fernandes AC, Linhares P, Vaz R, Lima J. The role of [[c-Met]] and [[VEGFR2]] in [[glioblastoma]] resistance to [[bevacizumab]]. Sci Rep. 2021 Mar 16;11(1):6067. doi: 10.1038/s41598-021-85385-1. PMID: 33727583.)).