Bromocriptine [Neurosurgery Wiki]

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====== Bromocriptine ======

[[Bromocriptine]] can restore [[fertility]]. Continued therapy during [[pregnancy]] is associated with a 3.3% [[incidence]] of congenital anomalies and 11% spontaneous [[abortion]] rate which is the same as for the general population. [[Estrogen]] elevation during [[pregnancy]] stimulates hyperplasia of lactotrophs and some [[prolactinoma]]s, but the risk of symptomatic enlargement of [[microadenoma]]s and totally intrasellar [[macroadenoma]]s is <3%, vs. 30% risk for macroadenomas
((Molitch ME. Pregnancy and the hyperprolactinemic woman. N Engl JMed. 1985; 312:1364–1370)).

====Bromocriptine during pregnancy====
Pituitary [[prolactinoma]] patients should continue the original dose of bromocriptine for at least 4 months instead of immediate withdrawal during pregnancy. For those with large adenoma, bromocriptine should be taken throughout pregnancy. Blood levels of [[prolactin]], [[progesterone]], [[human chorionic gonadotropin]] (HCG) and visual dysfunction should be monitored every 2 weeks. If the levels of progesterone and HCG are low, they should be timely supplemented.If prolactin rises too rapidly and visual dysfunction worsens, the dose of bromocriptine should be appropriately increased. Taking bromocriptine during pregnancy can significantly reduce the rate of embryo stopping without improving the rate of embryo deformity. Thus use of bromocriptine is both safe and necessary
((Lian W, Liu N, Wang R, Xing B, Yao Y. [Analysis of treating prolactinoma
patients with bromocriptine during pregnancy]. Zhonghua Yi Xue Za Zhi. 2015
Feb;95(7):511-514. Chinese. PubMed PMID: 25916926.
)).

[[Bromocriptine  for lactotroph pituitary neuroendocrine tumor medical treatment]]