Brain tumor treatment [Neurosurgery Wiki]

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====== Brain tumor treatment ======

{{rss>https://pubmed.ncbi.nlm.nih.gov/rss/search/1voC1dtl6l9QuheTswltGYfnUiar8lwNtDqL-mdecj-1FhPkFF/?limit=15&utm_campaign=pubmed-2&fc=20250509024538}}
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Conventional [[brain tumor treatment]] includes [[surgery]], [[radiotherapy]], and [[chemotherapy]]. However, [[resistance]] to treatment remains a problem with recurrence shortly following. The resistance to treatment may be caused by [[cancer stem cell]]s (CSCs), a subset of brain tumor cells with the affinity for self-renewal and differentiation into multiple [[cell lineage]]s.
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[[Physician]]s treating [[patient]]s with [[brain tumor]]s face a subgroup of well-educated people aiming to independently verify and possibly supplement and/or modify their prescribed care. With the steadily increasing use of [[internet resources]], this approach can be expected to expand. Physicians should be prepared to deal appropriately with this subgroup of patients and their relatives to ensure that self-help activities support but do not endanger optimal care
((Schröter S, Halatsch ME, Behnke-Mursch J, Mursch K. Self-help activities of
brain tumour patients and their relatives. Cent Eur Neurosurg. 2009
Feb;70(1):21-6. doi: 10.1055/s-0028-1087215. Epub 2009 Feb 5. PubMed PMID:
19197831.
)).

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===== Dexamethasone for brain tumor treatment =====
[[Dexamethasone for brain tumor treatment]]


===== Brain tumor surgery =====
The recommended first-line [[treatment]] for most brain tumors is undelayed aggressive resection
((Sanai N, Berger MS. Glioma extent of resection and its impact on patient outcome. Neurosurgery 2008;62(4):753-764.
((Lee CH, Kim DG, Kim JW, et al. The role of surgical resection in the management of brain metastases: a 17-year longitudinal study. Acta Neurochir (Wien) 2013;155(3):389-397.)).

see [[brain tumor surgery]].

People diagnosed with brain tumours enter new and unfamiliar worlds in which they must make complex and previously unimaginable decisions about care, treatment and how to live their lives. While decisions are increasingly based around care pathways, these are embedded in values that often fail to accord with those of patients. In this article, we examine the cases of people with a brain tumour and how they, their families and healthcare professionals navigate and intervene in the course of life-threatening disease. We use ethnographic data (2014-16) and modified social theory to highlight: (1) patients' interpretations of disease and care and how they might differ from dominant biomedical logics; (2) complexity and contingency in care decisions; (3) rapid and unanticipated change owing to disease and bodily change; and (4) how people find ways through a world that is continually in motion and which comes into being through the combined action of human and non-human agencies. Our modified 'healthscapes' approach provides an analytic that emphasises the constant precariousness of life with a brain tumour. It helps to explain the times when patients' feel bumped off the pathway and moments when they themselves step away to make new spaces for choice
((Llewellyn H, Higgs P, Sampson EL, Jones L, Thorne L. Topographies of 'care
pathways' and 'healthscapes': Reconsidering the multiple journeys of people with 
a brain tumour. Sociol Health Illn. 2017 Dec 12. doi: 10.1111/1467-9566.12630.
[Epub ahead of print] PubMed PMID: 29230815.
)).

===== Lovastatin for brain tumor treatment =====
[[Lovastatin for brain tumor treatment]].

===== CAR-T cell Therapy for brain tumor treatment =====

Tremendous success using [[CAR-T cell Therapy]] in hematological malignancies has garnered significant interest in developing such treatments for [[solid tumor]]s, including [[brain tumor]]s. This success, however, has yet to be mirrored in [[solid organ]] neoplasms. [[CAR-T cell]] function has shown limited efficacy against brain tumors due to several factors including the [[immunosuppressive tumor microenvironment]], [[blood-brain barrier]], and [[tumor-antigen heterogeneity]]. Despite these considerations, CAR T-cell therapy has the potential to be implemented as a treatment modality for brain tumors. Here, we review adult and pediatric brain tumors, including glioblastoma, diffuse midline gliomas, and medulloblastomas that continue to portend a grim prognosis. We describe insights gained from different preclinical models using CAR T therapy against various brain tumors and results gathered from ongoing clinical trials. Furthermore, we outline the challenges limiting CAR T therapy success against brain tumors and summarize advancements made to overcome these obstacles.

[[Glioblastoma CAR-T cell therapy]]