brain_biomechanics [Neurosurgery Wiki]

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The biomechanical characterization of human brain tissue is a challenging task because of its multiphasic nature, its compliant mechanical response, its multiple modes of loading, and its regional variation of mechanical properties. Another equally important challenge is understanding the brain’s mechanobiology, the reaction of its cells in response to changes in the mechanical environment. In the brain, neuronal signaling is mediated by force-generating proteins.
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Ohno et al
((Ohno N, Miyati T, Mase M, Osawa T, Kan H, Kasai H, Hara M, Shibamoto Y, Hayashi N, Gabata T, Matsui O. Idiopathic normal-pressure hydrocephalus: temporal changes in ADC during cardiac cycle. Radiology. 2011 Nov;261(2):560-5. doi: 10.1148/radiol.11101860. Epub 2011 Sep 7. PMID: 21900622.))
reported that the maximum change in the [[ADC]] ([[deltaADC]]) reflected the degree of the fluctuation of water molecules and the deltaADC was significantly higher in [[iNPH]].
Subsequently, it has been suggested that the deltaADC makes it possible to obtain [[brain biomechanics]] information such as [[intracranial]] [[compliance]].
((Miyati T, Mase M, Kasai H, Hara M, Yamada K, Shibamoto Y, Soellinger M, Baltes C, Luechinger R. Noninvasive MRI assessment of intracranial compliance in idiopathic normal pressure hydrocephalus. J Magn Reson Imaging. 2007 Aug;26(2):274-8. doi: 10.1002/jmri.20999. PMID: 17610284.)),
((Ohno N, Miyati T, Mase M, Osawa T, Kan H, Kasai H, Hara M, Shibamoto Y, Hayashi N, Gabata T, Matsui O. Idiopathic normal-pressure hydrocephalus: temporal changes in ADC during cardiac cycle. Radiology. 2011 Nov;261(2):560-5. doi: 10.1148/radiol.11101860. Epub 2011 Sep 7. PMID: 21900622.))